Germline mutations in BRCA1 and BRCA2 are relatively common in women with ovarian, fallopian tube, and peritoneal carcinoma (OC) causing a greatly increased lifetime risk of these cancers, but the frequency and relevance of inherited mutations in other genes is less well characterized. This study set out to determine the frequency and importance of germline mutations in cancer-associated genes in OC. They found that 18% of patients carried pathogenic germline mutations in genes associated with OC risk. Read more…
